These guidance articles are peer reviewed and provided to give research teams high quality and trustworthy information on how to conduct a task or resolve an issue in the design, conduct or reporting of a clinical trial. Articles are accompanied by resources, such as a template or example documents. These are free for you to download and adapt for your study. Please acknowledge www.globalhealthtrials.org if you use these.

A prospective, qualitative, multi-site study investigating the barriers and enablers to locally-led clinical trial conduct in Ethiopia, Cameroon, and Sri Lanka; here the protocol, methods and instroduction are available for readers. 

6th April 2017 • comment

Become a Cochrane citizen scientist. Anyone can join their collaborative volunteer effort.

23rd December 2016 • comment
11th November 2016 • comment

Around half of the clinical trials done on medicines we use today are not published; a tragic truth that needs to be changed.

24th October 2016 • comment

The team interview panel members talking about the Novartis Access Initiative's work on NCDs.

20th July 2016 • comment

Watch the Malaria Consortium's excellent video summary of the amazing progress that has been made to address malaria, and also highlighing the key challenges that remain.

24th May 2016 • comment

Roundup - including a WHO assessment on environmental influences of health, universal health insurance in Nigeria and medical tourism, and the new prophylactic HIV vaginal ring for women.

22nd April 2016 • comment

Interview with Dr. Frank Smith of No More Epidemics Campaign and Management Science for Health (MSH) to learn more about their campaign to end epidemics.

22nd April 2016 • comment

Join us in Oxford on the 25th of April to mark World Malaria Day 2016 at a series of talks and a panel discussion. The speakers will present their latest projects and help us to understand the unique and interconnected findings of their research.

14th April 2016 • comment

This Week In Global Health (TWiGH) - WHO Reform

by This Week in Global Health

Members of our TWiGH team dive into the proposed reforms set to reshape the World Health Organization and what this could mean for the future of Global Health!

21st March 2016 • comment

Recent calls have been made for rapid and responsible sharing of research data in public health emergencies and outbreaks.

8th February 2016 • comment

Sponsorship in non-commercial clinical trials

by Raffaella Ravinetto , Katelijne De Nys, Marleen Boelaert, Ermias Diro, Graeme Meintjes, Yeka Adoke, Harry Tagbor, Minne Casteels

Non-commercial clinical research plays an increasingly essential role for global health. Multiple partners join in international consortia that operate under the limited timeframe of a specific funding period.

8th January 2016 • comment

Professor Lang talks about doing difficult trials in difficult places - including malaria and ebola trials.

19th October 2015 • comment

New Public Management (public sector reforms which draw on business ideology) are increasingly seen in African ministries of health. This talk concentrates on the effects of NPM reform on Ethiopian hospitals and how efforts to be 'more business-like' have many unintended consequences for hospitals and patients.

15th May 2015 • comment

Professor Bongani M Mayosi from the Department of Medicine, Groote Schuur Hospital & University of Cape Town describes the transofmation of the science cohort in South Africa.

14th May 2015 • comment

In celebration of Global Health Trials' fifth birthday (May 11th 2015) Professor Trudie Lang, Principal Investigator of the programme, talks to us about why Global Health Trials was started, why people should share their experience, and what the future holds.

8th May 2015 • comment

Strengthening capacity to apply health research evidence in policy making: experience from four countries

by Sarah Hawkes, Bhupinder K Aulakh, Nidhee Jadeja, Michelle Jimenez, Kent Buse, Iqbal Anwar, Sandhya Barge, M. Oladoyin Odubanjo, Abhay Shukla, Abdul Ghaffar, Jimmy Whitworth

Little experience of strengthening the capacity of policy makers in low- and middle- income countries has been published to date. This article describe the experiences of five projects (in Bangladesh, Gambia, India and Nigeria) - author available to comment!

8th May 2015 • comment
30th April 2015 • comment

UK EQUATOR Centre Publication School: Writing research articles fit for purpose - Learn the secrets of success in writing, publishing, and disseminating your research. 6th Julay 2015, University of Oxford.

27th March 2015 • comment
24th February 2015 • comment

Discussing the study protocol part 2

by D. Shamley, N.Kramer, E.Allen, L.Workman, W.Smythe, C.Ovenstone, C.Reddy
30th January 2015 • comment

The Pan African Clinical Trials Registry

by Dr Tamara Kredo of the PACTR
31st December 2014 • comment

On the 19th September 2014, Global Health Trials Southern Africa held its Annual Faculty Meeting, themed Clinical Trial Site Project Management. You can download the presentations from the talk and leave feedback here.

30th October 2014 • comment

Professor Peter Piot, LSHTM, talks about Ebola and implications for Africa and understanding future epidemics at the Martin School, University of Oxford, 16th October 2014.

17th October 2014 • comment

Ebola PPE guidelines - urgent need to revise WHO and CDC guidelines. This video shows an excerpt from keynote address 'The fuss about face masks', Professor Raina MacIntyre from the School of Public Health and Community Medicine, UNSW Australia.

14th October 2014 • comment

This extensive toolkit was developed by TDR, and explains how to conduct implementation research. This toolkit was designed to help people learn a standard process that would lead to results that could be compared across regions and countries. It is designed to help identify system bottlenecks and the stakeholders to be involved, formulate appropriate research questions, conduct the research and develop a plan for implementing the study results.

29th July 2014 • comment

We have recently obtained permission to share some very interesting videos on The Global Health Network. The videos are from Global Health Videos by Greg Martin. You can follow more videos from him at his YouTube channel. This series of videos deal with Glolbal Health and Ethics.

2nd June 2014 • comment

This article, published in AIDS & Clinical Research, reports on a project aiming at building the capacity of regulatory agencies in Nigeria.

22nd January 2014 • comment

Social science guidance from the ACT Consortium available for wider research community, including training materials, SOPs, template protoclos and other tools.

13th January 2014 • comment

A systematic review of barriers to and facilitators of the use of evidence by policymakers (BMC article)

by Kathryn Oliver, Simon Innvar, Theo Lorenc, Jenny woodman, James Thomas

The gap between research and practice or policy is often described as a problem. To identify new barriers of and facilitators to the use of evidence by policymakers, and assess the state of research in this area, the authors present a systematic review.

10th January 2014 • comment

This guide, developed by the WHO and released in December 2013, aims to facilitate implementation research in LMICs.

2nd December 2013 • comment

A recent editorial in PLoS discusses the significance of transparency in reporting and publishing the studies and how scientific studies guidelines have evolved over time.

28th August 2013 • comment

Powerpoint slides representing a comprehensive overview of some issues surrounding data management, including an overview of data management, the issue of coding, and regulations and guidelines.     NEW ADDITIONS AUGUST 2013: Code of Federal Regulations part 11 - Guidelines on how to implement

3rd April 2013 • comment

This is a nice guidance document on principles in electronic data capture from Industry perspective (FDA)

18th March 2013 • comment

Research reporting guidelines are standard statements that provide guidance on how to report research methodology and findings. These are in the form of checklists, flow diagrams or texts. Most of the biomedical journals require authors to comply with these guidelines. Guidelines are available for reporting various study designs:

  • CONSORT Statement (reporting of randomized controlled trials)
  • STARD (reporting of diagnostic accuracy studies)
  • STROBE (reporting of observational studies in epidemiology)
  • PRISMA (reporting of systematic reviews)
  • MOOSE (reporting of meta-analyses of observational studies)

26th October 2012 • comment
19th July 2012 • comment

Clinical trials in India continue to be in the news, unfortunately a fair bit being negative coverage.

25th May 2012 • comment

The report from the Satellite Event at the Sixth EDCTP1 Forum, Addis Ababa, Ethiopia  United Nations Conference Centre, 11th October 2011: Clinical trials in practice: how to achieve the best protection of the study subjects?

29th November 2011 • comment

It is a recommendation of some IRB/ECs that back translation is included as a necessary step for the translation of some clinical trial documentation, including informed consent documents. This article explains the reasons for back translation, and takes you through how to effectively perform this step, including explaining how to find a suitable translator for the task.

9th June 2011 • comment

This paper, recently published on the Italian Journal of Tropical Medicine(Vol 15, N 1-4, 2010), reports on a debate that took place during the 6thEuropean Conference of Tropical Medicine in 2009, on some topics of greatinterest for GlobalHealthTrials.org: is there a global standard for clinicalresearch? Should standards be adapted in developing countries? How toencourage research while preventing the exploitation of vulnerableindividuals or groups? Five "debate questions" where addressed by ProfessorNick White and by Dr. Lumuli Mbonile, and discussed with the moderator(Raffaella Ravinetto) and the audience.

24th January 2011 • comment

The WHO invite comments on these new guidelines: Standards and Operational Guidance for Ethics Review of Health-Related Research with Human Participants

5th January 2011 • comment

A set of 4 consent templates for clinical trials, interview studies, observation studies and sampling only studies.

29th November 2010 • comment

This article explains how an East Africa Research Group have developed and applied a highly pragmatic an effective monitoring system. This group train research staff to monitor or perform QC on studies and then implement a system of reciprocal monitoring between studies. It is cost effective and works well.

5th November 2010 • comment

An overview on trial registration. Here you can find out why trials need to be registered and what the difference is between all the registries - and how to register your study.

1st November 2010 • comment

What is the definition of clinical trial monitoring? Who can be a monitor? What are the monitor's roles and responsibilities? Read on for some answers.

2nd February 2010 • comment

An overview of different types of clinical trial oversight committees, including steering committees and data safety monitoring committees.

21st November 2009 • comment

Clinical trial governance encompasses sponsorship, contracts, finance, confidentiality, trial insurance and professional indemnity and scientific and ethical review. You can find guidance and template documents relating to all of these topics throughout GlobalHealthTrials.org or you can contribute your own material to help others.

21st November 2009 • comment

Who should write up the results of the clinical trial? Are there guidelines on what should be included in the paper? This article answers these questions.

21st November 2009 • comment

Ticking the last box: once the trial has ended it is important to ensure correct site closure and archiving of study files.

21st November 2009 • comment

Considerations for pharmacovigilance and safety reporting.

21st November 2009 • comment

Reciprocal or in-house monitoring schemes could be an alternative to expensive out-sourcing. Read on to find out more.

21st November 2009 • comment

The site initiation process is important as it ensures that all the logistics are organised and the site is ready to begin recruiting subjects.

21st November 2009 • comment

What is the definition of a clinical trial? Is there an international consensus? Read on to find out.

21st November 2009 • comment

Good data management practices are essential to the success of a trial because they help to ensure that the data collected is complete and accurate. This article contains some tips to help you get started with data management.

21st November 2009 • comment

Clinical trial regulations can be confusing and unwieldy to researchers. The intention of this section is to explain what regulations exist, where they apply and how to work through them in a sensible and pragmatic way to determine what is applicable to any given trial.

21st November 2009 • comment

The informed consent process is fundamental to ensuring that clinical trials are conducted ethically. This article outlines some issues to consider.

21st November 2009 • comment