ORRCA (www.orrca.org.uk) is a free, online, searchable database of research around recruitment to Clinical Trials. It aims to help users identify promising recruitment interventions and inform the matching or tailoring of these interventions to specific recruitment challenges faced by different types of trial.
Development of an online resource for recruitment research in clinical trials to organise and map current literature
by Anna Kearney, Nicola Harman, Anna Rosala-Hallas, Claire Beecher, Jane Blazeby, Peter Bower, Mike Clarke, William Cragg, Sinead Dune, Heidi Gardner, Patricia Healy, Lisa Maguire, Nicola Mills, Leila Rooshenas, Ceri Rowlands, Shaun Treweek, Akke Vellinga, Paula Williamson, Carrol GambleTransparency in the conduct and reporting of clinical trials is supported by the guidance produced on the content of clinical trial protocols and reporting standards for clinical trials. While the principle features of the statistical analysis are required within this guidance it is generally accepted that a separate Statistical Analysis Plan is also developed as the level of detail appropriate for a SAP is excessive for a protocol. However, there is no detailed guidance on the content of a SAP and consequently, there is marked variation in practice.
Global Research Nurses Skill Sharing Workshop Report: Enugu Nigeria October 11th &12th 2018
by Ekezie Ralueke OluchukwuThe workshop was attended by 120 total participants over two days, and here we provide a report of the workshop, as well as all the presentations from the day.
Performance of different clinical trial designs to evaluate treatments during an epidemic
by Matthias Brueckner, Andrew Titman, Thomas Jaki, Amanda Rojek, Peter HorbyIn the 2013-2016 west Africa outbreak of Ebola Virus Disease (EVD), most of the planned clinical trials failed to reach a conclusion within the time frame of the epidemic. We conduct a comprehensive evaluation of commonly used two- and multi-arm clinical trial designs based on real data, which was recorded during the 2013-16 EVD epidemic in west Africa
Mental Health Awareness Month
by TGHN EditorialParticipate in Doctors Without Borders (MSF) survey on the value of sharing medical case reports from humanitarian and resource limited settings
by The Editorial TeamREPORT OF THE 2018 ONE DAY FREE WORKSHOP ON CLINICAL RESEARCH CAPACITY BUILDING FOR CLINICAL RESEARCH IN NIGERIA
by Glory Oluwagbenga Ogunfowokan - Regional Faculty Lead, morenike Ukpong, AUGUSTINE ONYEAGHALA - Senior Contributor, ogundokun Olusegun - Senior Contributor, Regional Faculty Committee Member, Ekezie Ralueke OluchukwuThis report details the workshop held on 7th July 2018 at the Nigerian Airforce Conference Centre, Abuja.
A Guide to Efficient Trial Management
by The Trial Manager's NetworkThis Guide to Efficient Trial Management, published by the Trial Manager's Network (UK) and available freely online, is a must for all trial managers or coordinators. This link is for the 6th Edition (2018)
Free Webinar: Science, technology and innovation for upskilling knowledge-based economies in Africa
by The Editorial TeamPragmatism in practice: lessons learned during screening and enrollment for a randomised controlled trial in rural northern Ethiopia
by Meseret Molla, Henok Negussie, Moses Ngari, Esther Kivaya, Patricia Njuguna, Fikre Enqueselassie, James A. Berkley, Gail DaveyWe use the example of the Gojjam Lymphoedema Best Practice Trial (GoLBeT), a pragmatic trial in a remote rural setting in northern Ethiopia, to extract lessons relevant to other investigators balancing the demands of practicality and community acceptability with internal and external validity in clinical trials.
Workshop Report: Collaborations and Partnerships for the conduct of Health Research in Nigeria
by Morenike Ukpong - Senior Contributor, Regional Faculty Committee, ogundokun Olusegun - Senior Contributor, Regional Faculty Committee MemberThe Nigerian Global Health Trial Conference 2018 took place on the 30th and 31st of January 2018 the Sickle Cell Centre, Idi-Araba, Lagos. The full report here is shared to allow others to experience and learn from the event.
Participant-level data and the new frontier in trial transparency
by Deborah A. ZarinWe have to learn as much as we can about the benefits, risks, costs, and appropriate role of disclosing participant-level data, in service to the ultimate goal of honoring each trial volunteer's altruism.
Access to regulatory data from the European Medicines Agency: the times they are a-changing
by Beate Wieseler, Natalie McGauran, Michaela F Kerekes, Thomas Kaisera milestone for data transparency in clinical research is within reach- it is hoped this is not unnecessarily delayed.
Data sharing: reaching consensus.
by Jimmy WhitworthJimmy Whitworth calls for a more sustainable and palatable pathway be will to build consensus and to create a broad coalition.
Mark Walport and Paul Brest argues that we need to ensure that research outputs are used to maximise knowledge and potential health benefits
Whose data set is it anyway? Sharing raw data from randomized trials
by Andrew VickersIn this paper, Andrew Vickers argues that attitudes towards data sharing in the clinical trial community need to rethought, drastically
A systematic review of barriers to data sharing in public health
by Willem G van Panhuis, Proma Paul, Claudia Emerson, John Grefenstette, Richard Wilder, Abraham J Herbst, David Heymann, Donald S BurkeThis study looks at the challneges of data sharing globally.