World TB Day 2012: Strengthening tuberculosis research in Africa

On the occasion of World Tuberculosis (TB) Day, 24 March 2012, the European and Developing Countries Clinical Trials Partnership (EDCTP) has published a short video that highlights some of the EDCTP funded TB research in sub-Saharan Africa.

In addition, this article presents several areas of development: new diagnostic tools, shorter treatment periods, prevention of TB, and safe treatment combinations in TB-HIV co-infected patients.

Saved once (save)
Bookmarked by The Editorial Team on 27 Mar 2012

After nearly a century of vaccination and six decades of drug therapy, tuberculosis (TB) kills more people annually than any other infectious disease. Substantial challenges to disease eradication remain among vulnerable and underserved populations. The Guarani-Kaiowá people are an indigenous population in Paraguay and the Brazilian state of Mato Grosso do Sul. This community, marginalized in Brazilian society, experiences severe poverty. Like other South American indigenous populations, their TB prevalence is high, but the disease has remained largely unstudied in their communities. Herein, Mycobacterium tuberculosis isolates from local clinics were whole genome sequenced, and a population genetic framework was generated. Phylogenetics show M. tuberculosis isolates in the Guarani-Kaiowá people cluster away from selected reference strains, suggesting divergence. Most cluster in a single group, further characterized as M. tuberculosis sublineage 4.3.3. Closer analysis of SNPs showed numerous variants across the genome, including in drug resistance-associated genes, and with many unique changes fixed in each group. We report that local M. tuberculosis strains have acquired unique polymorphisms in the Guarani-Kaiowá people, and drug resistance characterization is urgently needed to inform public health to ensure proper care and avoid further evolution and spread of drug-resistant TB.    

13th January 2021 • comment
3rd May 2019 • comment
28th January 2015 • comment

Effects of introducing Xpert MTB/RIF test on multi-drug resistant tuberculosis diagnosis in KwaZulu-Natal South Africa

by Nomonde R Dlamini-Mvelase, Lise Werner, Rogerio Phili, Lindiwe P Cele and Koleka P Mlisana
20th January 2015 • comment

The prison setting has been often cited as a possible reservoir of tuberculosis (TB) including multidrug-resistant (MDR)-TB. This is particularly true in low-income, high TB prevalence countries in Sub-Saharan Africa. A systemic literature review was done to assess the prevalence, drug resistance and risk factors for acquiring TB in the prison population. Our review indicated a high prevalence of TB in prisons which is reported to be 3- to 1000-fold higher than that found in the civilian population, indicating evidence and the need for public health policy formulation. In addition, high levels of MDR and extensively drug-resistant (XDR)-TB have been reported from prisons, which is a warning call to review prison TB control strategy. Multiple risk factors such as overcrowding, poor ventilation, malnutrition, human immunodeficiency virus (HIV), and others have fuelled the spread of TB in prisons.    

1st November 2014 • comment

New publication on rifampicin Mono-Resistance in TB

by Yacoob Mahomed Coovadia, Sharana Mahomed, Melendhran Pillay, Lise Werner, Koleka Mlisana
12th November 2013 • comment

Mobile Phone Based Clinical Microscopy for Global Health Applications

by David N. Breslauer, Robi N. Maamari, Neil A. Switz, Wilbur A. Lam, Daniel A. Fletcher
16th July 2012 • comment

Direct susceptibility testing for multi drug resistant tuberculosis: a meta-analysis

by Freddie Bwanga, Sven Hoffner, Melles Haile, Moses L Joloba
16th July 2012 • comment
16th July 2012 • comment
16th July 2012 • comment

Promise versus Reality: Optimism Bias in Package Inserts for Tuberculosis Diagnostics

by Claudia M. Denkinger, Jasmine Grenier, Jessica Minion, Madhukar Pai
13th July 2012 • comment

This review, written by Ruth McNerney and Peter Daley, provides an overview of the state of research into point-of-care diagnostics for active tuberculosis and highlights the barriers to the development of these tests.

2nd March 2012 • comment
16th February 2012 • comment

Evidence-Based Tuberculosis Diagnosis

by Madhukar Pai, Andrew Ramsay, Richard O'Brien
16th February 2012 • comment
13th February 2012 • comment

Coming soon! A paper series on clinical trial design for tropical diseases. Read more here and get involved!

21st November 2009 • comment