On the occasion of World Tuberculosis (TB) Day, 24 March 2012, the European and Developing Countries Clinical Trials Partnership (EDCTP) has published a short video that highlights some of the EDCTP funded TB research in sub-Saharan Africa.
In addition, this article presents several areas of development: new diagnostic tools, shorter treatment periods, prevention of TB, and safe treatment combinations in TB-HIV co-infected patients.
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Effects of introducing Xpert MTB/RIF test on multi-drug resistant tuberculosis diagnosis in KwaZulu-Natal South Africaby Nomonde R Dlamini-Mvelase, Lise Werner, Rogerio Phili, Lindiwe P Cele and Koleka P Mlisana
The prison setting has been often cited as a possible reservoir of tuberculosis (TB) including multidrug-resistant (MDR)-TB. This is particularly true in low-income, high TB prevalence countries in Sub-Saharan Africa. A systemic literature review was done to assess the prevalence, drug resistance and risk factors for acquiring TB in the prison population. Our review indicated a high prevalence of TB in prisons which is reported to be 3- to 1000-fold higher than that found in the civilian population, indicating evidence and the need for public health policy formulation. In addition, high levels of MDR and extensively drug-resistant (XDR)-TB have been reported from prisons, which is a warning call to review prison TB control strategy. Multiple risk factors such as overcrowding, poor ventilation, malnutrition, human immunodeficiency virus (HIV), and others have fuelled the spread of TB in prisons.
Rapid and Inexpensive Detection of MDR Mycobacterium tuberculosis using a Resazurin Microtitreplate Assay in a High Burden Tuberculosis Reference Laboratoryby Prenika Jaglal, Melendhran Pillay, Koleka Mlisana
This review, written by Ruth McNerney and Peter Daley, provides an overview of the state of research into point-of-care diagnostics for active tuberculosis and highlights the barriers to the development of these tests.