Andy Burke on 16 Sep 2010
The Nuffield Council on Bioethics is an independent body that examines and reports on ethical issues in biology and medicine. It was established by the Trustees of the Nuffield Foundation in 1991, and since 1994 it has been funded jointly by the Foundation, the Wellcome Trust and the Medical Research Council.
Sam Franzen on 27 Oct 2010
The Editorial Team on 12 Oct 2011
Article on SciDevNet about the launch of Global Health Reviewers, a partner site of Global Health Trials. www.GlobalHealthReviewers.org is an online community for members of research review committees, and aims to provide support, guidance, review and professional network.
The Editorial Team on 15 Nov 2011
TRREE is a multi-lingual web-based training program and capacity building initiative on the ethics of research involving humans. It is headed by a consortium of interested persons from Northern and Southern countries.
This site provides free-of-charge and open access to:
•e-Learning: a distance learning program and certification on research ethics evaluation &
The Editorial Team on 26 Apr 2012
An extensive document edited by Johan Karlberg and Marjorie Speers, with information for Ethics Review Committees, including an extensive introduction with information about ethics and bioethics, and how this relates to clinical research, how trials are designed and facotrs to consider when reviewing protocols.
Gendered negotiations for research participation in community-based studies: implications for health research policy and practiceby DM Kamuya, CS Molyneux, S Theobald
Enhancing quality and integrity in biomedical research in Africa: an international call for greater focus, investment and standardisation in capacity strengthening for frontline staffby Francis Kombe et al.
Experiencing everyday ethics in context: frontline data collectors perspectives and practices of bioethicsby Patricia Kingori et al.
Community Members Employed on Research Projects Face Crucial, Often Under-Recognized, Ethical Dilemmasby Sassy Molyneux et al.
Preparing for and Executing a Randomised Controlled Trial of Podoconiosis Treatment in Northern Ethiopiaby Henok Negussie, Thomas Addissie, Adamu Addissie, Gail Davey
This study highlights the utility of rapid ethical assessment prior to clinical trials involving complex procedures and concepts.
The practicality and sustainability of a community advisory board at a large medical research unit on the Thai-Myanmar borderby Khin Maung Lwin, Thomas J Peto, Nicholas J White, Nicholas P.J. Day, Francois Nosten, Michael Parker, phaikyeong
Community engagement is increasingly promoted to strengthen the ethics of medical research in low-income countries. One strategy is to use community advisory boards (CABs): semi-independent groups that can potentially safeguard the rights of study participants and help improve research. However, there is little published on the experience of operating and sustaining CABs.
“…..Noncommunicable diseases pose an increasingly high burden of disease that threatens economic and social development, yet cost-effective health interventions exist."
These guidelines were developed following a Working Group on Disaster Research and Ethics (WGDRE) meeting in 2007 with the aim of developing ethical guidelines which would be applicable to post-disaster research, partiuclarly that performed in the developing world. We welcome any feedback from members.
Genome-wide association studies (GWAS) provide a powerful means of identifying genetic variants that play a role in common diseases. Such studies present important ethical challenges. An increasing number of GWAS are taking place in lower income countries and there is a pressing need to identify the particular ethical challenges arising in such contexts. In this paper, we draw upon the experiences of the MalariaGEN Consortium to identify specific ethical issues raised by such research in Africa, Asia and Oceania.
This is a bibliography of articles on the topic of the theory and methodology of empirical ethics. This bibliography was last updated in June 2009, but is nonetheless included here as a potentially useful resource. We would like to keep this bibliography updated. Please let us know if we are missing any references - especially from the last two years.
This article was written by a researcher from Sri Lanka and presents a very helpful overview on Biomedical Ethics. This article will be helpful to all levels of research staff and others who might want an accessible overview
Clinical trial governance encompasses sponsorship, contracts, finance, confidentiality, trial insurance and professional indemnity and scientific and ethical review. You can find guidance and template documents relating to all of these topics throughout GlobalHealthTrials.org or you can contribute your own material to help others.
The site initiation process is important as it ensures that all the logistics are organised and the site is ready to begin recruiting subjects.
Clinical trial regulations can be confusing and unwieldy to researchers. The intention of this section is to explain what regulations exist, where they apply and how to work through them in a sensible and pragmatic way to determine what is applicable to any given trial.