Background High rates of virus transmission and the presence of variants of concern can affect vaccine effectiveness (VE). Both conditions occur in low-income countries, which primarily use viral vector or inactivated virus vaccine technologies. Such countries conducted few VE analyses, and most lack the power to evaluate effectiveness in subgroups.

3rd September 2021 • comment

Vaccines work by tricking your body into thinking it has been infected with a disease-causing organism (also called germs) such as a virus, prompting it to develop an immune reaction to the organism itself.

7th December 2020 • comment
26th October 2020 • comment
30th September 2020 • comment
25th June 2020 • comment

Vaccine Efficacy Assessment for COVID-19

by Edde Loeliger and Bob Small
7th May 2020 • comment

The SARS-CoV-2 pandemic presents an unprecedented challenge to global health with enormous health system, social and economic disruption and large numbers of deaths already experienced in many countries. Epidemiologic features confirm that ongoing spread to less affected areas is now a certainty.

20th March 2020 • comment

To maximize the value of vaccine safety data in clinical trials given their relatively limited sample size, it is essential to standardize their collection, presentation and analysis when possible.Given serious adverse events following immunization (AEFIs) are fortuitously rare, this need for globally accepted standard case definitions that allow for valid comparisons extend to individual case reports, surveillance systems, and retrospective epidemiologic studies.

5th March 2020 • comment