All content matching "Vaccines"

Influence of age on the effectiveness and duration of protection in Vaxzevria and CoronaVac vaccines

Background High rates of virus transmission and the presence of variants of concern can affect vaccine effectiveness (VE). Both conditions occur in low-income countries, which primarily use viral vector or inactivated virus vaccine technologies. Such countries conducted few VE analyses, and most lack the power to evaluate effectiveness in subgroups.

Questions and answers on COVID-19 vaccine

Vaccines work by tricking your body into thinking it has been infected with a disease-causing organism (also called germs) such as a virus, prompting it to develop an immune reaction to the organism itself.

A Comparison of Vaccine Efficacy Elements in Advanced Stage Clinical Trial Protocols

Evaluating the Burden-of-Disease Endpoint to Assess Vaccine Efficacy

COVID-19 Efficacy Endpoints in Interventional Trials: What Constitutes an Incident Clinical Disease Case and What Triggers Diagnostic Work-Up V2.0

CONSIDERATIONS FOR EVALUATION OF COVID19 VACCINES

Priority List of COVID-19 Adverse events of special interest: Quarterly update 1

Efficacy Endpoints in COVID-19 Vaccine Trials: SARS-CoV-2 Infection

Vaccine Efficacy Assessment for COVID-19

COVID-19 Efficacy Endpoints in Interventional Trials: What Constitutes an Incident Clinical Disease Case and What Triggers Diagnostic Work-Up

General Core Elements for Early Phase Clinical Trials of COVID-19 Vaccine Candidates: Aspects to Consider

Speed coronavirus vaccine testing by deliberately infecting volunteers? Not so fast, some scientists warn

Consensus considerations on the assessment of the risk of disease enhancement with COVID-19 vaccines:

The SARS-CoV-2 pandemic presents an unprecedented challenge to global health with enormous health system, social and economic disruption and large numbers of deaths already experienced in many countries. Epidemiologic features confirm that ongoing spread to less affected areas is now a certainty.

Priority List of Adverse Events of Special Interest: COVID-19

To maximize the value of vaccine safety data in clinical trials given their relatively limited sample size, it is essential to standardize their collection, presentation and analysis when possible.Given serious adverse events following immunization (AEFIs) are fortuitously rare, this need for globally accepted standard case definitions that allow for valid comparisons extend to individual case reports, surveillance systems, and retrospective epidemiologic studies.