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Often times, we screening patients to either identify a health condition we would like to recruit them for during a clinical study or screen to rule out health conditions that may make study volunteers ineligible for study participants. Screening for research participants however come with lots of ethical issues which may be challenges.First, I personally think it is unethical to screen patients for any disease condition for which that individual may not be able to access treatment. Oftentimes, when we screen volunteers for disease conditions, they are referred to medical institutions for management of the disease or condition. Yet, referral does not imply access to care as many patients may never get to the point of care due to several challenges. Unfortunately, out medical screening procedure had saddening made the individual conscious of a health problem (s)he may not have known about. This comes with attendant worries, anxieties and anxiety related morbidities. I am of the strong opinion that national research regulatory agencies should enforce that all research that would require study participants to screen for disease condition for the purpose of excluding them from research should ensure access of the screened individual to care and treatment. Individuals may opt out of treatment, but the research should make provision for such.Second, I also think disease screening programmes should be part of an holistic project that addresses the needs of a population. Uncoordinated screening programmes that allows researchers indiscriminate access to study participants ends up being beneficial for the researchers and less so for the public health good. It is important that countries, especially those in developing countries, institute policies, laws and guidelines that regulates screening programmes for research purposes