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The International Subarachnoid Aneurysm Trial (ISAT), is the first and currently only large, multicentre prospective randomised trial of surgery compared with endovascular coil treatment of acute subarachnoid haemorrhage in the world. It aims to recruit up to 3,000 patients in about 25 centres in four years. This will produce the largest ever prospective randomised study in aneurysmal subarachnoid haemorrhage management. The clinical ramifications and impact on healthcare costs will be of major significance if substantial differences are found in the outcome according to randomised procedure.al, to assess reliably whether treatment of neonatal sepsis with IVIG reduces mortality and adverse neuro-developmental outcome. It needs no special expertise and can be conducted simultaneously with other studies.
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