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The FEAST trial is an excellent example of a high quality international standard clinical trial being conducted in very challenging settings. 
This film gives remarkable insight into how the team worked to make sure this robust trial could answer the difficult question that it was designed to address in very sick children in remote African hospitals.
Please do comment on this film and share any experiences that you have.
 
https://www.youtube.com/watch?v=GdMMuURsZQg